Toshikazu Ushijima


National Cancer Center, Tokyo

Dr. Toshikazu Ushijima, Senior Deputy Director and Chief of Division of Epigenomics, National Cancer Center Research Institute (NCCRI), Tokyo, graduated from University of Tokyo School of Medicine in 1986.  He developed one of the first genome-wide screening techniques for changes in DNA methylation, methylation-sensitive representational difference analysis (MS-RDA), in 1997 [PNAS, 94:2284, 1997].  Using MS-RDA, he isolated a novel tumor-suppressor gene in gastric cancers [Cancer Res, 64:6410, 2004] and a "clinical-grade" prognostic marker in neuroblastomas [Cancer Res, 65:828, 2005].  He established the concept of "epigenetic field for cancerization" [Clin Cancer Res, 12:989, 2006], demonstrated that inflammation triggered by Helicobacter pylori is critical for induction of aberrant DNA methylation [Cancer Res, 70:1430, 2010], and is now investigating its molecular mechanisms [Clin Cancer Res, 18:923, 2012].  He is serving as editors of multiple journals, including Cancer Research, Cancer Letters, Cancer Science, and Gastric Cancer, and as a member of International Scientific Steering Committee of the International Human Epigenome Consortium.